One way to create storage space if a user receives the "Startup Disk is Full" message is to delete older versions of Chrome.  Here is the process:

  • Control-click on Chrome in applications and show package contents. 

  • Go to the Contents folder and click the triangle.

  • Go to the Versions folder and click the triangle to show the contents.

  • Delete all prior versions of Chrome.  
  • Go to the Finder and Empty Trash.